Hughes Publications

Recent Publications

2012

Remi-Martin Laberge, Lili Zhou... Judith Campisi "Glucocorticoids Suppress Selected Components of the Senescence-Associated Secretory Phenotype." Aging cell 11:4 569-578

Melissa R Sarantos, Theodora Papanikolaou... Robert E Hughes "Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease." J Huntingtons Dis 1:2 195-210

John P Miller, Bridget E Yates... Robert E Hughes "A Genome-Scale RNA-Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease." PLoS Genet. 8:11 e1003042

Theodore W Peters, Matthew J Rardin... Robert E Hughes "Tor1 regulates protein solubility in Saccharomyces cerevisiae." Mol. Biol. Cell 23:24 4679-88

Pooja Agrawal, Yu-Ting Chen... Robert E Hughes "Ubiquitin Specific Peptidase 9, X-linked (USP9X) Modulates the Activity of Mammalian Target of Rapamycin (mTOR)." The Journal of biological chemistry 287:25 21164-75

2011

Pedro Reis-Rodrigues, Gregg Czerwieniec... Robert E Hughes "Proteomic Analysis of Age-dependent Changes in Protein Solubility Identifies Genes that Modulate Lifespan." Aging cell 11:1 120-7

John P. Miller and Robert E. Hughes, ... John P. Miller and Robert E. Hughes "Protein Interactions and Target Discovery in Huntington’s Disease." In: Lo DC, Hughes RE, editors, Neurobiology of Huntington's Disease: Applications to Drug Discovery. Boca Raton (FL): CRC Press. Chapter 3.

2010

Hemant Varma, Ai Yamamoto... Brent R Stockwell "MUTANT HUNTINGTIN ALTERS CELL FATE IN RESPONSE TO MICROTUBULE DEPOLYMERIZATION VIA GEF-H1-RHOA-ERK PATHWAY." The Journal of biological chemistry 285:48 37445-57

Carlos Gorbea, Gregory Pratt... Martin Rechsteiner "A protein interaction network for ECM29 links the 26S proteasome to molecular motors and endosomal components." The Journal of biological chemistry 285:41 31616-33

John P Miller, Jennifer Holcomb... Lisa M Ellerby "Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease." Neuron 67:2 199-212

2009

Russell Bell, Alan Hubbard... Robert E Hughes "A human protein interaction network shows conservation of aging processes between human and invertebrate species." PLoS Genet. 5:3 e1000414

2008

Marissa Vignali, Anastasia McKinlay... Stanley Fields "Interaction of an atypical Plasmodium falciparum ETRAMP with human apolipoproteins." Malar. J. 7 211

Eliana Romero, Guang-Ho Cha... Juan Botas "Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm." Neuron 57:1 27-40

2007

Linda S Kaltenbach, Eliana Romero... Robert E Hughes "Huntingtin interacting proteins are genetic modifiers of neurodegeneration." PLoS Genet. 3:5 e82

2005

Douglas J LaCount, Marissa Vignali... Robert E Hughes "A protein interaction network of the malaria parasite Plasmodium falciparum." Nature 438:7064 103-7

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