Past Kennedy Lab Members

 Steven Chen

Steven Chen
Steven joined the Kennedy lab as a graduate student in 2007 after completing his degrees in Biochemistry, Cell and Molecular Biology, and Music at the University of Washington. He remained in Seattle to finish his PhD in the lab of Paul Lampe at the Fred Hutchinson Cancer Research Center. He has worked on many different projects, but his current work attempts to elucidate the molecular mechanism behind the development of dilated cardiomyopathy and conduction defects in laminopathies by studying lamin-deficient mice and cells. He is slated to graduate in 2012.

Lindus Conlan
Lindus earned her PhD from the University of Melbourne in Australia in 2002 and then spent two years as a post-doc in the lab of Jorg Heierhorst at St.Vincent's Institute where she studied the assembly of dynamic structures in the nucleus in response to damage of the genome.

She came from Australia in 2003 to work as a post-doc in Brian Kennedy's lab at the University of Washington, studying the structure of the cell nucleus, aging, tumorigenesis, and the American way of life. She examined the spatial organisation of the Retinoblastoma protein, DNA replication and lamin A and how these are misregulated in cancer and aging models.  Lindus returned in 2006 to continue her work in the Heierhorst lab, asking how the temporal and spatial organisation of structures in the nucleus relate to functions such as gene expression and the DNA damage response and how dysregulation of these functions lead to cancer.

http://www.svi.edu.au/research_units/molecular_genetics

Published Articles
Nitta RT, Jameson SA, Kudlow BA, Conlan LA, Kennedy BK. Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest. Mol Cell Biol. 2006 Jul;26(14):5360-72.

Jurado S, Conlan LA, Baker EK, Ng JL, Tenis N, Hoch NC, Gleeson K, Smeets M, Izon D & Heierhorst J (2012).  Atm substrate chk2-interacting Zn2+-finger (ASCIZ) is a bi-functional transcriptional activator and feedback sensor of dynein light chain (DYNLL1) expression.  J. Biol. Chem.  287

 Richard Frock

Richard Frock
Richard was a graduate student mentored by Brian Kennedy and Steve Hauschka at the University of Washington and studied A-type nuclear lamin function in striated muscle and the immune system.  After receiving his PhD in Biochemistry, Richard joined the lab of Frederick Alt at Harvard Medical School as a Research Fellow in the Program in Cellular and Molecular Medicine at Children's Hospital Boston where he is utilizing next generation sequencing technologies to study the mechanisms of DNA double strand break repair and genomic instability.

http://www.idi.harvard.edu/

 

Mike Garelick
Mike Garelick received his PhD at the University of Washington, studying biochemical events in the brain that support memory function and how these events can change during aging. He joined the Kennedy lab in 2009, interested in how the cellular regulation of translation might contribute to longevity. Mike investigated the translation in two long-lived mouse models: mice treated with the drug rapamycin and mice lacking the S6K1 gene. For family reasons, Mike was unable to follow the lab to California. He is now working at a second post doc at New York University, where he studies how the interaction between neurons and glia support normal function in the mammalian brain.  

 Stephan Guyenet

Stephan Guyenet
Stephan J. Guyenet received a BS in Biochemistry from the University of Virginia, and a PhD in Neurobiology from the University of Washington. For his thesis work, he studied the protein Ataxin-7, focusing on its relationship to the neurodegenerative disorder spinocerebellar ataxia type 7, as well as the role of Ataxin-7 in the cellular aging process.  In Dr. Kennedy's lab, he focused on investigating the longevity phenotype of yeast strains lacking Sgf73, the yeast ortholog of Ataxin-7.  He is currently a postdoc in the lab of Michael W. Schwartz, investigating the neurobiological mechanisms of diet-induced obesity at the University of Washington.  He publishes a health and nutrition blog called Whole Health Source.

 

Damian C. Lee
dclee@uwalumni.com
Previous project with Brian: Identified and characterized a novel transcription repression function of A-type lamins.

 

Don Lockshon 

 Chris Pobre

Chris Pobre
Chris is a Dominican University Master's student who joined the lab in August 2010. Previously he received his degree in Biological Sciences and a minor in Chemistry, also from Dominican University of California. Here at the Buck, his research mainly focuses on the model organisms of Saccharomyces cerevisiae and Caenorhabditis elegans along with the effects of different compounds and drugs in relation to lifespan.

 Brett Robison

Brett Robison
brobison@berkeley.edu
Brett is a former undergraduate researcher and technician in the Kennedy lab.  He received his BS in Biochemistry from the University of Washington and is currently pursuing a PhD in Molecular and Cell Biology at UC Berkeley.  While in the lab, Brett helped uncover a role for the highly conserved ubiquitin/proteasome system in regulating replicative lifespan in S. cerevisiae. 

 

Tom Schmidlin
Tom worked in the Kennedy Lab at the University of Washington, first as a student researcher and later as a graduate student, studying mating in diploid yeast. He earned his PhD in Biochemistry from UW in 2011 focusing on mutations in superoxide dismutase that are associated with Lou Gehrig's Disease as analyzed by molecular dynamics methods. In his current work in the UW Department of Bioengineering, he continues to use molecular dynamics and experimental methods to study various human diseases.

 

Joanna Sitzmann

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